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Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.
Mitchell CA, Verovskaya EV, Calero-Nieto FJ, Olson OC, Swann JW, Wang X, Hérault A, Dellorusso PV, Zhang SY, Svendsen AF, Pietras EM, Bakker ST, Ho TT, Göttgens B, Passegué E. Mitchell CA, et al. Among authors: svendsen af. Nat Cell Biol. 2023 Jan;25(1):30-41. doi: 10.1038/s41556-022-01053-0. Epub 2023 Jan 17. Nat Cell Biol. 2023. PMID: 36650381 Free PMC article.
T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice.
Bazioti V, La Rose AM, Maassen S, Bianchi F, de Boer R, Halmos B, Dabral D, Guilbaud E, Flohr-Svendsen A, Groenen AG, Marmolejo-Garza A, Koster MH, Kloosterhuis NJ, Havinga R, Pranger AT, Langelaar-Makkinje M, de Bruin A, van de Sluis B, Kohan AB, Yvan-Charvet L, van den Bogaart G, Westerterp M. Bazioti V, et al. Among authors: flohr svendsen a. Nat Commun. 2022 Jul 1;13(1):3799. doi: 10.1038/s41467-022-31135-4. Nat Commun. 2022. PMID: 35778407 Free PMC article.
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N, Trumpp A. Renders S, et al. Among authors: svendsen af. Nat Commun. 2021 Jan 27;12(1):608. doi: 10.1038/s41467-020-20801-0. Nat Commun. 2021. PMID: 33504783 Free PMC article.
Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity.
Kim KM, Mura-Meszaros A, Tollot M, Krishnan MS, Gründl M, Neubert L, Groth M, Rodriguez-Fraticelli A, Svendsen AF, Campaner S, Andreas N, Kamradt T, Hoffmann S, Camargo FD, Heidel FH, Bystrykh LV, de Haan G, von Eyss B. Kim KM, et al. Among authors: svendsen af. Nat Commun. 2022 Sep 3;13(1):5187. doi: 10.1038/s41467-022-32970-1. Nat Commun. 2022. PMID: 36057685 Free PMC article.
CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness genes and can be targeted by the BCL2 inhibitor venetoclax.
Mattes K, Gerritsen M, Folkerts H, Geugien M, van den Heuvel FA, Svendsen AF, Yi G, Martens JHA, Vellenga E. Mattes K, et al. Among authors: svendsen af. Haematologica. 2020 Aug;105(8):e399-e403. doi: 10.3324/haematol.2019.229997. Epub 2019 Nov 14. Haematologica. 2020. PMID: 31727766 Free PMC article. No abstract available.